ChloroquineV1, Main, Exploration, bibRecord, 002465

Endosomes, lysosomes: their implication in gene transfer

Identifieur interne : 002465 ( Main/Exploration ); précédent : 002464; suivant : 002466

Endosomes, lysosomes: their implication in gene transfer

Auteurs : Robert Wattiaux [Belgique] ; Nathanael Laurent [Belgique] ; Simone Wattiaux-De Coninck [Belgique] ; Michel Jadot [Belgique]

Source :

Advanced Drug Delivery Reviews [ 0169-409X ] ; 2000.

RBID : ISTEX:294649C0501AD453A8340826A4FD6CF1D9A87587

English descriptors

Teeft :
- Biochem, Cationic, Cationic lipids, Cationic vectors, Complexed, Coninck, Cytosol, Drug delivery reviews, Endocytosed, Endocytosis, Endosomal, Endosomal compartment, Endosomes, Gene delivery, Gene transfer, Intracellular, Intracellular fate, Isopycnic centrifugation, Lipid, Lysosomal, Lysosomal membrane, Lysosomal membranes, Lysosomal nucleases, Lysosome, Nuclease, Organelle, Other hand, Peptide, Phase endocytosis, Plasma membrane, Plasmid, Polyethyleneimine, Receptor, Scavenger receptors, Sucrose, Sucrose gradient, Transfection, Wattiaux.

Abstract

Abstract: Plasmid DNA, naked or bound to a non-viral vector, is taken up by endocytosis. As a result, it has to travel through the intracellular endocytic pathway involving endosomes and lysosomes. However, some DNA molecules must escape these organelles to reach the nucleus where transcription takes place. In this paper, we consider different factors that could affect the trafficking of plasmid DNA and influence transfection efficiency.

Url:

https://api.istex.fr/ark:/67375/6H6-SJFNZBBZ-1/fulltext.pdf

DOI: 10.1016/S0169-409X(99)00066-6

Affiliations:

Belgique

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Le document en format XML

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<term>Cytosol</term>
<term>Drug delivery reviews</term>
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<front><div type="abstract" xml:lang="en">Abstract: Plasmid DNA, naked or bound to a non-viral vector, is taken up by endocytosis. As a result, it has to travel through the intracellular endocytic pathway involving endosomes and lysosomes. However, some DNA molecules must escape these organelles to reach the nucleus where transcription takes place. In this paper, we consider different factors that could affect the trafficking of plasmid DNA and influence transfection efficiency.</div>
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Endosomes, lysosomes: their implication in gene transfer

Endosomes, lysosomes: their implication in gene transfer

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri